![]() ![]() In addition to serving as principal investigator of the Mitochondrial Neurobiology and Therapeutics Lab, she is a professor of neurology and a professor of pharmacology at Mayo Clinic College of Medicine and Science in Rochester. The Hackettstown School District is pleased to announce our continued partnership with Lab-Q Diagnostics to ensure a. ![]() Trushina's goal is to develop new treatments that can delay the onset of symptoms and improve quality of life for patients. Trushina has expertise in a range of neurodegenerative diseases. Our model systems include primary neuronal cultures, primary and immortalized human cell lines, multiple animal models, and human biofluids and tissue. Systems biology techniques that include metabolomics, transcriptomics, proteomics and epigenetics.Surface plasmon resonance technology (Biacore) for drug development.Flow cytometry analysis of mitochondria subpopulations.Fluorescence, confocal and super-resolution microscopy.A Seahorse extracellular flux analyzer to assay respiration.Wet-lab classical biochemistry methods.In subsequent studies, our team identified small molecules that restore mitochondrial dynamics and axonal trafficking, which in animal models of Alzheimer's disease led to protection of cognitive function and significant delays in the onset of symptoms. ![]() This work justified the restoration of axonal trafficking as a therapeutic strategy that targets early mechanisms of disease. For example, based on basic science research, our research team identified the inhibition of axonal trafficking of mitochondria as the underlying molecular dysfunction in Alzheimer's disease. To manage Your Account: to manage Your registration as a user of the Service. Studies in our lab provide a foundation for the development of disease-modifying mitochondria-targeted interventions. The Company may use Personal Data for the following purposes: To provide and maintain our Service, including to monitor the usage of our Service. Trushina's work could benefit people with Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and metabolic disorders. Trushina's research in her Mitochondrial Neurobiology and Therapeutics Laboratory focuses on understanding the early molecular mechanisms of these diseases, with a special emphasis on the contributing role of altered mitochondrial dynamics and function. OverviewĮugenia Trushina, Ph.D., is determined to find better treatments for a variety of neurodegenerative diseases that currently have limited options. This work is one example of our push to better understand early molecular mechanisms of disease and find new treatment options. This image shows a 3D electron microscopy reconstruction of mitochondria in the hippocampus of an Alzheimer's disease model. A leading blood test laboratory in India, Dr Lal PathLabs offers diagnostic services & wide range of diagnostic tests. ![]()
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